New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Destiné à l'étudiant en philosophie, ou aux personnes disposant déjà d'une solide culture philosophique, cet ouvrage se présente sous la forme d'une introduction à la métaphysique. Inscrit dans la tradition thomiste, mais ouvert au dialogue avec d'autres traditions de pensée - et notamment les écrits de Maurice Blondel - il tente une défense et un essai de synthèse de sa discipline. Après une introduction discutant de la définition, des sources, de la méthode et des présupposés théologiques de la métaphysique, (...) il s'occupe, dans une première partie, de la saisie intellectuelle de l'« être » quant à ses pôles objectif et subjectif. Il approfondit ensuite la question de la possibilité d'une connaissance métaphysique et engage la discussion entre réalisme et anti-réalisme. Dans une seconde partie, il traite de l'approche rationnelle de Dieu. Il tente, à nouveaux frais, un essai de démonstration de l'existence de Dieu, avant d'approfondir la question du statut analogique de la connaissance de Dieu à laquelle l'homme peut parvenir. Il poursuit et conclut avec les questions traditionnelles de la nature divine, de l'acte créateur, du statut de la créature et de l'éventuelle prémonition rationnelle d'une pluralité en Dieu."-- Back cover. (shrink)

Qu'est-ce qui oriente la philosophie? Depuis Platon, le philosophe est celui qui tourne son regard vers le Bien et qui adopte une manière de vivre en accord avec sa pensée. Qu'est devenue cette manière de vivre comme exigence philosophique, pour un philosophe qui se laisse inspirer par la révélation chrétienne? Faut-il la nommer "sainteté"? Cet ouvrage présente six philosophes du XXe siècle qui ont cherché à accorder leur pensée et leur manière de vivre : Maurice Blondel, Erich Przywara, Simone (...) Weil, Aimé Forest, Michel Henry, Edith Stein. Des philosophes à l'écoute d'une inspiration qui oriente leur existence. La philosophie comme un acte de résistance spirituelle. Il y a là beaucoup à apprendre. (shrink)

Preface and Acknowledgments Introduction. The Galileo Affair from Descartes to John Paul II: A Survey of Sources, Facts, and Issues 1. The Condemnation of Galileo 2. Promulgation and Diffusion of the News 3. Emblematic Reactions: Descartes, Peiresc, Galileo’s Daughter 4. Polarizations: Secularism, Liberalism, Fundamentalism 5. Compromises: Viviani, Auzout, Leibniz 6. Myth-making or Enlightenment? Pascal, Voltaire, the Encyclopedia 7. Incompetence or Enlightenment? Pope Benedict XIV 8. New Lies, Documents, Myths, Apologies 9. Napoleonic Wars and Trials 10. The Inquisition on Galileo’s (...) Side? The Settele Affair and Beyond 11. Varieties of Torture: Demythologizing Galileo’s Trial? 12. A Miscarriage of Justice? The Documentation of Impropriety 13. Galileo Right Again, Wrong Again: Hermeneutics, Epistemology, "Heresy" 14. A Catholic Hero: Tricentennial Rehabilitation 15. Secular Indictments: Brecht’s Atomic Bomb and Koestler’s Two Cultures 16. History on Trial: The Paschini Affair 17. More "Rehabilitation": Pope John Paul II Epilogue: Unfinished Business. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Hans-Georg GADAMER, Hermeneutische Entwürfe. Vorträge und Aufsätze ; Pascal MICHON, Poétique d’une anti-anthropologie: l’herméneutique deGadamer ; Robert J. DOSTAL, The Cambridge Companion to Gadamer ; Denis SERON, Le problème de la métaphysique. Recherches sur l’interprétation heideggerienne de Platon et d’Aristote ; Henry MALDINEY, Ouvrir le rien. L’art nu ; Dominique JANICAUD, Heidegger en France, I. Récit; II. Entretiens ; Maurice MERLEAU-PONTY, Fenomenologia percepţiei ; Trish GLAZEBROOK, Heidegger’s Philosophy of Science ; Richard WOLIN, Heidegger’s Children. Hannah Arendt, Karl Löwith, (...) Hans Jonas and Herbert Marcuse ; Ivo DEGENNARO, Logos – Heidegger liest Heraklit ; O. K. WIEGAND, R. J. DOSTAL, L. EMBREE, J. KOCKELMANS and J. N. MOHANTY, Phenomenology on Kant, German Idealism, Hermeneutics and Logic ; James FAULCONER and Mark WRATHALL, Appropriating Heidegger. (shrink)

In recent years, the European Union has advanced towards responsible and sustainable Artificial Intelligence (AI) research, development and innovation. While the Ethics Guidelines for Trustworthy AI released in 2019 and the AI Act in 2021 set the starting point for a European Ethical AI, there are still several challenges to translate such advances into the public debate, education and practical learning. This paper contributes towards closing this gap by reviewing the approaches that can be found in the existing literature and (...) by interviewing 11 experts across five countries to help define educational strategies, competencies and resources needed for the successful implementation of Trustworthy AI in Higher Education (HE) and to reach students from all disciplines. The findings are presented in the form of recommendations both for educators and policy incentives, translating the guidelines into HE teaching and practice, so that the next generation of young people can contribute to an ethical, safe and cutting-edge AI made in Europe. (shrink)

Until recently, more scholarly careers were being devoted to the study of the teaching of St Thomas Aquinas than to any other philosophical or theological doctrine, with the possible exception of Marxism. Roman Catholic scholars have tended, however, to isolate his philosophical theology from its neo-Platonism, while others have treated the various parts of his Summa Theologiae without regard to their historical context. Dr Hankey's main contention is that Aquinas was less of an Aristotelian than is commonly supposed, and (...) that a proper appreciation of his work requires us to take fuller notice of his reliance on neo-Platonism. In setting out his case, Dr Hankey pays special attention to the influence of Proclus, whose work receives a critical exposition. The author supports his position by making a careful analysis of the first 45 questions of the Summa Theologiae. (shrink)

First published in 1945, Maurice Merleau-Ponty’s monumental _Phénoménologie de la perception _signalled the arrival of a major new philosophical and intellectual voice in post-war Europe. Breaking with the prevailing picture of existentialism and phenomenology at the time, it has become one of the landmark works of twentieth-century thought. This new translation, the first for over fifty years, makes this classic work of philosophy available to a new generation of readers. _Phenomenology of Perception _stands in the great phenomenological tradition of (...) Husserl, Heidegger, and Sartre. Yet Merleau-Ponty’s contribution is decisive, as he brings this tradition and other philosophical predecessors, particularly Descartes and Kant, to confront a neglected dimension of our experience: the lived body and the phenomenal world. Charting a bold course between the reductionism of science on the one hand and "intellectualism" on the other, Merleau-Ponty argues that we should regard the body not as a mere biological or physical unit, but as the body which structures one’s situation and experience within the world. Merleau-Ponty enriches his classic work with engaging studies of famous cases in the history of psychology and neurology as well as phenomena that continue to draw our attention, such as phantom limb syndrome, synaesthesia, and hallucination. This new translation includes many helpful features such as the reintroduction of Merleau-Ponty’s discursive Table of Contents as subtitles into the body of the text, a comprehensive Translator’s Introduction to its main themes, essential notes explaining key terms of translation, an extensive Index, and an important updating of Merleau-Ponty’s references to now available English translations. Also included is a new foreword by Taylor Carman and an introduction to Merleau-Ponty_ _by Claude Lefort. Translated by Donald A. Landes. (shrink)

Marx says of alienated labor that it does not "belong" to the worker, that it issues in a product that does not belong to her, and that it is unfulfilling, unfree, egoistically motivated, and inhuman. He seems to think, moreover, that the first of these features grounds all the others. All of these features seem quite independent, however: they can come apart; they share no obvious common cause or explanation; and if they often occur together this seems accidental. It is (...) not clear, then, how Marx's concept of alienated labor could possess the strong unity which he takes it to have. I defend a reinterpretation of the concept which explains this unity. The various features of alienated labor, I argue, all follow from a single, hitherto underappreciated feature of its formal motivational structure: the fact that such labor is motivated not by its product but by an incentive. (shrink)

Euripides’ Alcestis (1959) raises the issue of ethical duties within families and exposes the romantic postures and rhetoric that can dominate such discussions. Should anybody be asked to sacrifice themselves or even undergo significant health risks for members of their own family? (An issue that is also relevant in considering our duties to future generations in terms of the earth we leave to them.) The issue that is dramatized to a heroic level in Alcestis arises in live organ and tissue (...) donation within a family and challenges the idea that families should be trusted to sort out solutions that they can all live with. Alcestis intensifies the debate because the sacrifice of one life for another is its topic but, in doing so, it exposes many traps lying in wait for ethicists and medical jurists who boldly enter such debates (where emotions create shifting ground on which angels fear to tread). (shrink)

Le sceptique nous demande " Comment sais-tu que tu as deux mains? Peut-être rêves-tu, ou es-tu trompé par quelque Malin Génie? Peut-on même définir ce que c'est que la connaissance? Va savoir! " Lui rétorquer, comme le faisaient G.E. Moore et la tradition de la philosophie du sens commun : " Mais je sais bien que j'ai deux mains! " semble à la fois une pétition de principe et une bien mauvaise réponse. Le mieux, depuis que nous avons perdu le (...) souci de fonder nos croyance sur des raisons ultimes, serait, tout simplement, de ne pas se soucier des questions du sceptique. Ce que l'on sait dépend, nous dit-on, des circonstances, et toutes nos connaissances sont faillibles. N'y a-t-il pas plutôt des savoirs, dont l'histoire nous montre combien leurs modes de validations sont variés? Ce livre entend refuser ce type de réponse contextualiste et relativiste. Il propose de revenir à la réponse de sens commun de Moore, à partir des reformulations contemporaines des raisonnements sceptiques issues de la philosophie analytique de la connaissance. Personne ne peut nous envoyer savoir quelque chose que nous ne pourrions pas savoir. De fait, nous savons, mais notre savoir n'est pas transparent : nous n'avons pas besoin de savoir que nous savons. Pour parvenir à cette réponse, il faut replacer la notion de connaissance, plutôt que celle de croyance justifiée ou rationnelle, au centre de l'épistémologie, et reformuler des questions traditionnelles comme celles de la nature de la perception, du témoignage, et de la connaissance a priori. On peut aussi reprendre le vieux projet d'une enquête sur la nature de la connaissance en général. (shrink)

Fairness is central to the ethical and responsible development and use of AI systems, with a large number of frameworks and formal notions of algorithmic fairness being available. However, many of the fairness solutions proposed revolve around technical considerations and not the needs of and consequences for the most impacted communities. We therefore want to take the focus away from definitions and allow for the inclusion of societal and relational aspects to represent how the effects of AI systems impact and (...) are experienced by individuals and social groups. In this paper, we do this by means of proposing the ACROCPoLis framework to represent allocation processes with a modeling emphasis on fairness aspects. The framework provides a shared vocabulary in which the factors relevant to fairness assessments for different situations and procedures are made explicit, as well as their interrelations. This enables us to compare analogous situations, to highlight the differences in dissimilar situations, and to capture differing interpretations of the same situation by different stakeholders. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 29.2 (2005) 269-285 [Access article in PDF] Oedipus The King: Temperament, Character, and Virtue Grant Gillett Robin Hankey University of Otago I Recent discussions of ethics and literature suggest that there is a relationship between reading (or, better, immersing oneself in) literature (in particular, fiction) and the virtues. Nussbaum goes so far as to claim not only that good literature is conducive to moral sense (...) and sensibility but also that "the well-lived life is a work of literary art."1 The character development in most substantial fictional work that aims to engage us through its realism and truth to the human condition suggests that there is such a thing as a quasi-stable character and that an agent's character plays a significant role in the way not only that the person acts but also in the kinds of thing that happen to him or her. For a certain kind of virtue theorist, the internal harmony of character required for a person to do the right thing in a diverse range of situations involves cultivating exactly those skills required to live well. This thesis amounts to a claim that there is a close, indeed conceptual, relationship between right living and good living and that the type of character which results from cultivating the virtues is a character conducive to getting the best out of the situations that life throws in our way, whereas the vicious character reveals itself by causing strife, harm, and even tragedy.Gilbert Harman, criticizing virtue ethics on the basis of some key experiments in social psychology which have led to the idea of a "fundamental attribution error," argues that people do not have enduring character traits of the type required to sustain such a position.2 His critique has itself been attacked on the basis that what the experiments show is not the absence of character traits but their ability [End Page 269] to be influenced by the demands of a situation.3 Our objection is against the conception of virtues being attacked and also his sweeping conclusion about human nature and it has two strands. First we argue that phronesis, as the hallmark of a virtuous character, is a mix of skills, abilities, and attitudes honed in such a way as to allow the person to act fittingly in different life situations. Second, character runs true to type in an individual and even runs in families.We find support for both claims in Sophocles' Oedipus the King. This is, of course, a myth but one that has spoken to human beings across the ages and it recognizes both that different individuals show certain regularities in their modes of relationship and their conduct and that these tendencies are often familial, contributing significantly to the events marking family stories and traditions. Phronesis or practical wisdom is the skill to negotiate the challenges that life produces when fate deals one a hand of this (genetic and genealogical) kind. In the process of making the case we will support the claim that fiction "can significantly contribute to moral understanding by revealing what certain situations amount to" and therefore that it "can bring home to us the force of, for example, moral dilemmas" and indeed moral concepts, and we will use the Oedipus story to reflect on the lessons emerging from one version of virtue ethics.4We approach the Oedipus myth through Sophocles' tragedy in which an oracle about patricide and incest plays itself out in the lives of certain characters. The relevance for virtue ethics arises from the ways in which characters in the play react to their predicament and try to cope with the situations they must face. In moral life, individuals need to find strategies to deal with challenges they face both as individuals and as persons-in-relationships-with-others. The reactions portrayed in Oedipus make vivid not only the idea of character traits but also the role of virtue in moderating what we might do in situations that interact with our characters in potentially disastrous ways. II Harman's challenge begins... (shrink)

Etude sur la philosophie de la technique et la pensée de l'individuation chez Gilbert Simondon qui interroge les notions de progrès, d'aliénation et de mémoire et leur devenir lors des grands changements de l'histoire des techniques (tradition, révolution industrielle, cybernétique). Met également en lumière son rapport à la psychologie des profondeurs, au sacré et à la technoesthétique.

Thick terms and concepts, such as honesty and cruelty, are at the heart of a variety of debates in philosophy of language and metaethics. Central to these debates is the question of how the descriptive and evaluative components of thick concepts are related and whether they can be separated from each other. So far, no empirical data on how thick terms are used in ordinary language has been collected to inform these debates. In this paper, we present the first empirical (...) study, designed to investigate whether the evaluative component of thick concepts is communicated as part of the semantic meaning or by means of conversational implicatures. While neither the semantic nor the pragmatic view can fully account for the use of thick terms in ordinary language, our results do favour the semanticist interpretation: the evaluation of a thick concept is only slightly easier to cancel than semantically entailed content. We further discovered a polarity effect, demonstrating that how easily an evaluation can be cancelled depends on whether the thick term is of positive or negative polarity. (shrink)

Bundel filosofische essays over kunst en esthetica.

Opstellen over de invloed van de Duitse filosoof (1889-1976) op de filosofie in Nederland. Bevat bibliografie.

Since its origin, bioethics has attracted the collaboration of few social scientists, and social scientific methods of gathering empirical data have remained unfamiliar to ethicists. Recently, however, the clouded relations between the empirical and normative perspectives on bioethics appear to be changing. Three reasons explain why there was no easy and consistent input of empirical evidence into bioethics. Firstly, interdisciplinary dialogue runs the risk of communication problems and divergent objectives. Secondly, the social sciences were absent partners since the beginning of (...) bioethics. Thirdly, the meta‐ethical distinction between ‘is’ and ‘ought’ created a ‘natural’ border between the disciplines. Now, bioethics tends to accommodate more empirical research. Three hypotheses explain this emergence. Firstly, dissatisfaction with a foundationalist interpretation of applied ethics created a stimulus to incorporate empirical research in bioethics. Secondly, clinical ethicists became engaged in empirical research due to their strong integration in the medical setting. Thirdly, the rise of the evidence‐based paradigm had an influence on the practice of bioethics. However, a problematic relationship cannot simply and easily evolve into a perfect interaction. A new and positive climate for empirical approaches has arisen, but the original difficulties have not disappeared. (shrink)

It has recently been argued that normative considerations play an important role in causal cognition. For instance, when an agent violates a moral rule and thereby produces a negative outcome, she will be judged to be much more of a cause of the outcome, compared to someone who performed the same action but did not violate a norm. While there is a substantial amount of evidence reporting these effects, it is still a matter of debate how this evidence is to (...) be interpreted. In this paper, we engage with the three most influential classes of explanations, namely, (a) the Norm‐Sensitive Cognitive Process View, (b) the Normative Concept View, and (c) the Pragmatics View. We will outline how these theories explain the empirical results and in what ways they differ. We conclude with a reflection on how well these strategies do overall and what questions they still leave unanswered. (shrink)

Presents results of free‐recall experiments conducted in France, Gabon and Nepal, to test predictions of a cognitive model of religious concepts. The world over, these concepts include violations of conceptual expectations at the level of domain knowledge (e.g., about ‘animal’ or ‘artifact’ or ‘person’) rather than at the basic level. In five studies we used narratives to test the hypothesis that domain‐level violations are recalled better than other conceptual associations. These studies used material constructed in the same way as religious (...) concepts, but not used in religions familiar to the subjects. Experiments 1 and 2 confirmed a distinctiveness effect for such material. Experiment 3 shows that recall also depends on the possibility to generate inferences from violations of domain expectations. Replications in Gabon (Exp. 4) and Nepal (Exp. 5) showed that recall for domain‐level violations is better than for violations of basic‐level expectations. Overall sensitivity to violations is similar in different cultures and produces similar recall effects, despite differences in commitment to religious belief, in the range of local religious concepts or in their mode of transmission. However, differences between Gabon and Nepal results suggest that familiarity with some types of domain‐level violations may paradoxically make other types more salient. These results suggest that recall effects may account for the recurrent features found in religious concepts from different cultures. (shrink)